CyFlow™ SCIMP Purified

Application:	Flow cytometry, Immunocytochemistry, Immunoprecipitation, Western blot
Clonality:	monoclonal
Target Species:	Human
Regulatory Status:	RUO
Source Species:	Mouse
Format/Fluorochrome:	Purified
Isotype:	IgG2a
Field of Interest:	Adaptor proteins
Antigen:	SCIMP
Clone:	NVL-07
Order number:	CQ058504

CHF 257.69 *

Prices net excl. VAT, plus applicable shipping costs

Delivery time appr. 3-5 workdays

Concentration Unit mg/mL Concentration 1 Quantity 0.1 mg Volume 0.1 mL... more

Product information "CyFlow™ SCIMP Purified"

Concentration Unit	mg/mL
Concentration	1
Quantity	0.1 mg
Volume	0.1 mL
Immunogen	Recombinant intracellular part of human SCIMP
Background Information	SCIMP (SLP adaptor and Csk interacting membrane protein), also known as Nvl, is a palmitoylated transmembrane adaptor protein expressed in professional antigen presenting cells, most prominently in the lymph nodes and spleen. It is associated with tetraspanin-enriched microdomains (together with MHC II). There is a close relationship between SCIMP and tyrosinkinase Lyn, which is constitutively bound to it by its SH3 domain. After MHC II-mediated stimulation in the immunological synapse SCIMP becomes phosphorylated at several tyrosine residues and provides docking sites for Grb2 and SLP65 or SLP76 adaptors transducing the signal downstream, as well as for the kinase Csk with modulatory roles.
Storage Buffer	The reagent is provided in phosphate buffered saline (PBS) solution, pH ≈7.4, containing 0.09% (w/v) sodium azide.
Storage	Avoid prolonged exposure to light. Store in the dark at 2-8°C. Do not freeze.
Stability	Do not use after expiration date stamped on vial label.

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